Polyclonal antibodies raised against the human erythrocyte nucleoside transporter were used to investigate the distribution of the nucleoside transporters in the placenta. Immunoblots of brush-border membranes isolated from the human syncytiotrophoblast revealed a cross-reactive species that co-migrated with the erythrocyte nucleoside transporter as a broad band of apparent M 55,000. In contrast, no labelling was detected in basal membranes containing a similar number of equilibrative nucleoside transporters as assessed by nitrobenzylthioinosine -binding. The absence of cross-reactive epitopes in basal membranes and (...) their presence in brush-border membranes was confirmed by confocal immunofluorescence microscopy. The results suggest that at least two isoforms of the NBMPR-sensitive nucleoside transporter are present in the human placenta. The lumenal surfaces of fetal capillaries, small placental vessels and umbilical vein ware also strongly labelled by the antibody, a finding that suggests that the high fetal-placental adenosine uptake previously reported is due to endothelial transporters. (shrink)

Last year's meetings of the leaders of the party and government with groups of creative artists caused a stir in the field of esthetics, placed in the foreground discussion of questions concerning the theory of the realistic image, and led to an examination of the experience accumulated in the party's struggle for socialist realism. In recent years, as a consequence of the spread of mathematical methods of research into the social sciences and even into creative work, old doubts with respect (...) to the specific significance of the creative image in art have again arisen. For several years now, efforts have been made in esthetics to emphasize, as distinctive features of art, other factors in artistic creativity, more accessible to study by the techniques of the natural sciences. (shrink)

The concept of alienation has taken firm root in the field of esthetics. One cannot say that its content is identical in everything one reads. Nonetheless, employment of this concept is always for the purpose, so to speak, of "clarification." It is often employed on the assumption that its use permits one to make clear whatever may be incomprehensible in the form and content of a work of art. It has become customary to have recourse to the concept of alienation (...) in esthetic analysis of modern foreign works of literature and art. As an example, we may cite the international discussion around the work of Franz Kafka, many participants in which hold that Kafka is a "product of alienation," "a prisoner of alienation," and that his work either expresses "his self-alienation" or involves depiction of the "consequences of alienation.". (shrink)

Joachim Schulte’s introduction provides a distinctive and masterful account of the full range of Wittgenstein’s thought. It is concise but not compressed, substantive but not overloaded with developmental or technical detail, informed by the latest scholarship but not pedantic. Beginners will find it accessible and seasoned students of Wittgenstein will appreciate it for the illuminating overview it provides.

Possible distributive justice frameworks for providing health care by general practitioners are discussed. The ethical considerations before and after the recent changes to the British National Health Service are contrasted, with particular emphasis on a possible ethical divide that has been produced between fund-holding and non-fund-holding general practitioners. It is argued that general practitioners in non-fund-holding practices can continue as ethical advocates for their patients and distribute health care within an egalitarian framework. However, those in fund-holding practices may now be (...) seen as interest advocates and may have to practise utilitarian distributive justice. Patient groups may be needed to ensure that these general practitioners are seen to act justly in the distribution of the health care resources for which they are now responsible. (shrink)

In the anthropology of Gregory of Elvira there converge different lines of thought. On the one hand he is very dependent on Origen, on the other there is to be found in him the mental framework of Irenaeus and he quotes word for word long passages from Tertullian. The article attempts to determine to what extent, starting from those influences he encountered, Gregory has developed a personal vision of the relationship between Adam and Christ along the double line of the (...) Pauline parallel : sin and grace, initial creation and eschatological fulfilment. If some characteristic passages stress much this second aspect, the majority of the texts analyzed concentrate primarily on the theme of redemption. The reason for the prefiguration of Christ in the creation of Adam, so important for Irenaeus and Tertullian, does not have in Gregory the prominent place which one might have expected to find. (shrink)

The relation between Jesus and the Spirit appears in diverse occasions and in different contexts in Gregory. Jesus has sanctified the waters in his baptism, from his body springs the Spirit whom he has received in the Jordan, he is the «anointed», the «Christ» par excellence who gives the Holy Spirit to people at Pentecost. The theology of the baptism of the Lord calls for special attention; it takes place at an interesting moment of transition. On the one hand, the (...) effusion of the Spirit on the humanity of Jesus does not create any problem for Gregory who distinguishes it clearly from the incarnation of the Son. On the other hand, the initiative of the Father in this unction is not paid special attention to, nor does it seem that it has a special significance for Jesus himself and the beginning of his mission in the world. However, much stress is given to the ecclesiological dimension of the descent of the Spirit in the baptism of Christ. On him comes the Spirit in fullness, as he will also abide in fullness in the whole Church which is his Body. Each of the Christians receives only a partial gift which must contribute to the perfection of the whole. (shrink)

IntroductionThe identity thesis asserts that for every psychological state P there is a neural state N such that P=N. In the hope of rendering IT clear and plausible many identity theorists have compared psycho-neural identity claims to such theoretical identities as temperature is identical with molecular mean kinetic energy. However such a comparison admits a weak and a strong interpretation. According to the weak interpretation, psycho-neural identities are said to be like theoretical identities in the sense that the former are (...) contingent claims just as the latter are presumed to be. Identity theorists have appealed to the contingent status of IT in order to meet prima facie objections of the following sort. We can imagine ourselves undergoing a pain, although we are not undergoing the neural process which the identity theorist claims is identical with the pain. Indeed we can imagine ourselves being in pain and yet not having a brain at all. Hence IT is false. Identity theorists have replied by arguing that this objection merely shows that IT is not a necessary truth, or that psychological and neurological terms do not have the same meaning. (shrink)